| 產(chǎn)品編號(hào) | IHC0445H |
| 英文名稱 | Human MBD1 Ready-To-Use IHC Kit |
| 中文名稱 | 人甲基化CpG結(jié)合蛋白即用型免疫組化試劑盒 |
| 別 名 | CXXC3; MBD1; PCM1; RFT |
| 適用樣品基質(zhì) | FFPE tissue |
| 保存條件 | Please store components at the temperatures indicated on the individual tube labels. The kit is stable for 6 months from the date of receipt. |
| 產(chǎn)品介紹 |
Methyl-CpG-binding domain protein 1 (MBD1) is a member of a family of mammalian proteins that specifically bind methylated regions of DNA. It is a transcriptional repressor that binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. Binding is abolished by the presence of 7-mG that is produced by DNA damage by methylmethanesulfonate (MMS). MBD1 acts as a transcriptional repressor and plays a role in gene silencing by recruiting AFT7IP, which in turn recruits factors such as the histone methyltransferase SETDB1. Isoform 1 and isoform 2 can also repress transcription from unmethylated promoters. SWISS: Q9UIS9 Gene ID: 4152 |
| 產(chǎn)品圖片 |
Immunohistochemical analysis of paraffin embedded human testis tissue slide using IHC0445H (Human MBD1 IHC Kit).
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