| 產(chǎn)品編號 | bsm-60555R |
| 英文名稱 | SUV39H1 Recombinant Rabbit mAb |
| 中文名稱 | 組蛋白H3 K9甲基轉(zhuǎn)移酶重組兔單抗 |
| 別 名 | SUV91_HUMAN; Histone-lysine N-methyltransferase SUV39H1; KMT1A; UV39H; EC:2.1.1.355; Histone H3-K9 methyltransferase 1(H3-K9-HMTase 1); Lysine N-methyltransferase 1A; Position-effect variegation 3-9 homolog; Suppressor of variegation 3-9 homolog 1(Su(var) |
| 抗體來源 | Rabbit |
| 克隆類型 | Recombinant |
| 克 隆 號 | E2B10 |
| 交叉反應(yīng) | Human (predicted: Mouse) |
| 產(chǎn)品應(yīng)用 | WB=1:200-1000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 48 kDa |
| 檢測分子量 | |
| 細(xì)胞定位 | 細(xì)胞核 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 亞 型 | IgG/Kappa |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
This gene encodes an evolutionarily-conserved protein containing an N-terminal chromodomain and a C-terminal SET domain. The encoded protein is a histone methyltransferase that trimethylates lysine 9 of histone H3, which results in transcriptional gene silencing. Loss of function of this gene disrupts heterochromatin formation and may cause chromosome instability. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013] 組蛋白甲基轉(zhuǎn)移酶，以單乙基化H3‘Lys-9’為底物，特異性地對組蛋白H3的‘Lys-9’進(jìn)行三甲基化。也有弱甲基化組蛋白H1（體外）。H3‘Lys-9’三甲基化通過向甲基化組蛋白中招募HP1（CBX1、CBX3和/或CBX5）蛋白，代表表觀遺傳轉(zhuǎn)錄抑制的一個(gè)特定標(biāo)記。主要作用于異鉻酸鹽區(qū)，在周中心區(qū)和端粒區(qū)的本構(gòu)性異染色質(zhì)的建立中起著重要作用。H3'Lys-9'三甲基化也需要在中心周重復(fù)點(diǎn)直接DNA甲基化。SUV39H1通過與RB1相互作用而以組蛋白H3為靶點(diǎn)，參與了抑制肌D1刺激分化、調(diào)控細(xì)胞周期退出和進(jìn)入分化的控制開關(guān)、PML-RARA融合蛋白的抑制、BMP誘導(dǎo)的抑制等過程，抑制IgA的開關(guān)重組和端粒長度的調(diào)節(jié)。 |
| 產(chǎn)品圖片 |
Blocking buffer: 5% NFDM/TBST
Primary ab dilution: 1:1000
Primary ab incubation condition: 2 hours at room temperature
Secondary ab: Goat Anti-Rabbit IgG H&L (HRP)
Lysate: HeLa, A431, 3T3
Protein loading quantity: 20 μg
Exposure time: 60 s
Predicted MW: 48 kDa
Observed MW: 48 kDa
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