| 產(chǎn)品編號 | bsm-52830R |
| 英文名稱 | NQO1 Recombinant Rabbit mAb |
| 中文名稱 | 醌氧化還原酶重組兔單抗 |
| 別 名 | Azoreductase; Cytochrome b 5 reductase; DHQU; DIA 4; DIA4; Diaphorase(NADH/NADPH)(cytochrome b 5 reductase); Diaphorase(NADH/NADPH)(cytochrome b-5 reductase); Diaphorase(NADH/NADPH)(cytochrome b-5 reductase); Diaphorase(NADH/NADPH); Diaphorase 4; Dioxin i |
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Specific References (1) | bsm-52830R has been referenced in 1 publications.
[IF=1.789] Zeba Farooqui . et al. Nrf2 inhibition induces oxidative stress, renal inflammation and hypertension in mice. Clin Exp Hypertens. 2021;43(2):175-180 WB ; Mouse.
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| 研究領(lǐng)域 | 腫瘤 信號轉(zhuǎn)導(dǎo) 合成與降解 新陳代謝 |
| 抗體來源 | Rabbit |
| 克隆類型 | Recombinant |
| 克 隆 號 | 8T5 |
| 交叉反應(yīng) | Human,Mouse,Rat |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000,Flow-Cyt=1:50-100,ICC/IF=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 31 kDa |
| 檢測分子量 | |
| 細(xì)胞定位 | 細(xì)胞漿 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human NQO1 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
This gene is a member of the NAD(P)H dehydrogenase (quinone) family and encodes a cytoplasmic 2-electron reductase. This FAD-binding protein forms homodimers and reduces quinones to hydroquinones. This protein's enzymatic activity prevents the one electron reduction of quinones that results in the production of radical species. Mutations in this gene have been associated with tardive dyskinesia (TD), an increased risk of hematotoxicity after exposure to benzene, and susceptibility to various forms of cancer. Altered expression of this protein has been seen in many tumors and is also associated with Alzheimer's disease (AD). Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq]. Function: The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinons involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis. Subunit: Homodimer. Subcellular Location: Cytoplasm. Similarity: Belongs to the NAD(P)H dehydrogenase (quinone) family. SWISS: P15559 Gene ID: 1728 Database links: Entrez Gene: 1728 Human Entrez Gene: 18104 Mouse Omim: 125860 Human SwissProt: P15559 Human SwissProt: Q64669 Mouse Unigene: 406515 Human Unigene: 252 Mouse Unigene: 11234 Rat |
| 產(chǎn)品圖片 |
25 ug total protein per lane of various lysates (see on figure) probed with NQO1 monoclonal antibody, unconjugated (bsm-52830R) at 1:2000 dilution and 4°C overnight incubation. Followed by conjugated secondary antibody incubation at r.t. for 60 min.
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