| 產(chǎn)品編號 | bs-10859R |
| 英文名稱 | IL-1 Beta Rabbit pAb |
| 中文名稱 | 白介素1β/IL-1β抗體 |
| 別 名 | IL1B_HUMAN; Interleukin-1 beta; interleukin 1 beta; IL1F2; IL-1 beta; Catabolin; IL-1; IL1F2; IL1beta; IL1-BETA; IL-1beta; IL-1 beta; IL-1β; IL1β; IL-1B; IL1B; 白細(xì)胞介素-1β; |
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Specific References (2) | bs-10859R has been referenced in 2 publications.
[IF=2.838] Li, Lu. et al. Luteolin alleviates inflammation and autophagy of hippocampus induced by cerebral ischemia/reperfusion by activating PPAR gamma in rats. BMC Complementary Medicine and Therapies. 2022 Dec;22(1):1-13 ELISA ; Rat.
[IF=1.813] Jiang Yan. et al. Exploring the Mechanism of Berberine Intervention in Ulcerative Colitis from the Perspective of Inflammation and Immunity Based on Systemic Pharmacology. Evid-Based Compl Alt. 2021;2021:9970240 IHC ; Rat.
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| 研究領(lǐng)域 | 細(xì)胞生物 免疫學(xué) 生長因子和激素 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 克 隆 號 | |
| 交叉反應(yīng) | Human,Mouse (predicted: Bee) |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 17/32 kDa |
| 檢測分子量 | |
| 細(xì)胞定位 | 分泌型蛋白 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | Recombinant human IL-1B protein: 117-269/269 (C-6x His-Tag) |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. [provided by RefSeq, Jul 2008]. Function: Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells. Subunit: Monomer. Subcellular Location: Secreted. Note=The lack of a specific hydrophobic segment in the precursor sequence suggests that IL-1 is released by damaged cells or is secreted by a mechanism differing from that used for other secretory proteins. Similarity: Belongs to the IL-1 family. SWISS: P01584 Gene ID: 3553 Database links: Entrez Gene: 3553 Human Entrez Gene: 16176 Mouse Omim: 147720 Human SwissProt: P01584 Human SwissProt: P10749 Mouse Unigene: 126256 Human Unigene: 222830 Mouse Unigene: 9869 Rat 生長因子和激素（ Growth Factor and Hormones） IL-1β是一種糖蛋白，它既可誘導(dǎo)急性期時相關(guān)蛋白的產(chǎn)生，也是β細(xì)胞終末分化并分泌抗體的必需因子，在免疫調(diào)節(jié)中發(fā)揮重要做 用。 IL-1β前體在細(xì)胞內(nèi)合成后被酶剪切為成熟形態(tài)后排出到細(xì)胞外,IL-1β的前體有153個氨基酸。成熟形態(tài)有116個氨基酸。 |
| 產(chǎn)品圖片 |
Sample:
Lane 1: Recombinant mouse IL-1b protein, C-His
Primary: Anti-IL-1 Beta (bs-10859R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 17/32 kDa
Observed band size: 25 kDa
Sample:
Lane 1: Recombinant human IL-1b protein
Primary: Anti-IL-1 Beta (bs-10859R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 17/32 kDa
Observed band size: 15 kDa
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