| 產(chǎn)品編號(hào) | bs-17529R |
| 英文名稱 | OSTA Rabbit pAb |
| 中文名稱 | 有機(jī)溶質(zhì)轉(zhuǎn)運(yùn)蛋白亞基α抗體 |
| 別 名 | Organic solute transporter subunit alpha; OST-alpha. |
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Specific References (3) | bs-17529R has been referenced in 3 publications.
[IF=6.388] Fangle Liu. et al. Nigakinone alleviates DSS-induced experimental colitis via regulating bile acid profile and FXR/NLRP3 signaling pathways. PHYTOTHER RES. 2022 Aug;: WB ; Rat.
[IF=3.826] Luan, Z et al. Discovery of new iridoids as FXR agonists from Morinda officinalis: Agonistic potentials and molecular stimulations WB ; Human.
[IF=3.69] Meiqi Wang. et al. Network pharmacology-based mechanism prediction and pharmacological validation of Xiaoyan Lidan formula on attenuating alpha-naphthylisothiocyanate induced cholestatic hepatic injury in rats. J Ethnopharmacol. 2021 Apr;270:113816 WB ; Rat.
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| 研究領(lǐng)域 | 腫瘤 細(xì)胞生物 信號(hào)轉(zhuǎn)導(dǎo) 新陳代謝 |
| 抗體來(lái)源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Human,Mouse,Rat,Rabbit,Pig,Dog,Horse) |
| 產(chǎn)品應(yīng)用 | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ICC/IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 37 kDa |
| 檢測(cè)分子量 | |
| 細(xì)胞定位 | 細(xì)胞膜 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human OSTA: 1-100/340 <Extracellular> |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
OSTA is an essential component of the Ost-alpha/Ost-beta complex, a heterodimer that acts as the intestinal basolateral transporter responsible for bile acid export from enterocytes into portal blood. It efficiently transports the major species of bile acids. Function: Essential component of the Ost-alpha/Ost-beta complex, a heterodimer that acts as the intestinal basolateral transporter responsible for bile acid export from enterocytes into portal blood. Efficiently transports the major species of bile acids. {ECO:0000269|PubMed:16317684}. Subunit: Interacts with SLC51B. The Ost-alpha/Ost-beta complex is a heterodimer composed of alpha (SLC51A) and beta (SLC51B) subunit (By similarity). {ECO:0000250}. Subcellular Location: Cell membrane; Multi-pass membrane protein Tissue Specificity: Widely expressed with a high expression in ileum. Expressed in testis, colon, liver, small intestine, kidney, ovary and adrenal gland; and at low levels in heart, lung, brain, pituitary, thyroid gland, uterus, prostate, mammary gland and fat. {ECO:0000269|PubMed:12719432, ECO:0000269|PubMed:16317684}. Similarity: Belongs to the OST-alpha family. {ECO:0000305}. SWISS: Q86UW1 Gene ID: 200931 Database links: Entrez Gene: 200931 Human Omim: 612084 Human SwissProt: Q86UW1 Human |
