| 產(chǎn)品編號 | bs-14356R |
| 英文名稱 | DNA Polymerase epsilon p59 Rabbit pAb |
| 中文名稱 | DNA聚合酶εp59/DNA pol εp59抗體 |
| 別 名 | DNA polymerase epsilon subunit 2; DNA polymerase epsilon subunit B; DNA polymerase II subunit 2; DPE 2; DPE2; DPOE2_HUMAN; POLE 2; POLE2; Polymerase(DNA directed) epsilon 2(p59 subunit); Polymerase(DNA directed) epsilon 2; polymerase(DNA directed), epsilon 2, accessory subunit; Polymerase, DNA, epsilon-2. |
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Specific References (3) | bs-14356R has been referenced in 3 publications.
[IF=11.205] Cong Lan. et al. Inhibition of DYRK1A, via histone modification, promotes cardiomyocyte cell cycle activation and cardiac repair after myocardial infarction. EBIOMEDICINE. 2022 Aug;82:104139 WB ; Rat.
[IF=5.201] Zhang Chuanjie. et al. Targeting POLE2 Creates a Novel Vulnerability in Renal Cell Carcinoma via Modulating Stanniocalcin 1. Front Cell Dev Biol. 2021 Feb;9:228 IHC ; Human.
[IF=4.175] Yongjun Zhu. et al. POLE2 knockdown reduce tumorigenesis in esophageal squamous cells. Cancer Cell Int. 2020 Dec;20(1):1-12 IHC ; Human.
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| 研究領(lǐng)域 | 細胞生物 表觀遺傳學(xué) |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 克 隆 號 | |
| 交叉反應(yīng) | Human,Mouse (predicted: Rat,Sheep,Cow,Horse) |
| 產(chǎn)品應(yīng)用 | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 59 kDa |
| 檢測分子量 | |
| 細胞定位 | 細胞核 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human DNA Polymerase epsilon p59: 101-200/527 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
DNA replication, recombination and repair, all of which are necessary for genome stability, require the presence of exonucleases Function: Participates in DNA repair and in chromosomal DNA replication. Subcellular Location: Nucleus. Similarity: Belongs to the DNA polymerase epsilon subunit B family. SWISS: P56282 Gene ID: 5427 Database links: Entrez Gene: 5427 Human Omim: 602670 Human SwissProt: P56282 Human Unigene: 162777 Human |
| 產(chǎn)品圖片 |
Tissue/cell: human laryngo carcinoma; 4% Paraformaldehyde-fixed and paraffin-embedded;
Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min;
Incubation: Anti-POLE2 Polyclonal Antibody, Unconjugated(bs-14356R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining
Tissue/cell: Mouse embryos tissue; 4% Paraformaldehyde-fixed and paraffin-embedded;
Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min;
Incubation: Anti-DNA Polymerase epsilon p59 Polyclonal Antibody, Unconjugated(bs-14356R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining
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