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CaMKK1 Rabbit pAb (bs-11247R)  
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產(chǎn)品編號 bs-11247R
英文名稱 CaMKK1 Rabbit pAb
中文名稱 鈣調(diào)蛋白激酶激酶α抗體CaMKKα
別    名 CaMKKa; Calcium/calmodulin dependent protein kinase kinase alpha; CaM kinase kinase alpha; Ca2+/calmodulin-dependent protein kinase kinase alpha; Calcium/calmodulin dependent protein kinase kinase; Calcium/calmodulin dependent protein kinase kinase 1 alpha; Calcium/calmodulin dependent protein kinase kinase 1; Calcium/calmodulin-dependent protein kinase kinase 1; Calcium/calmodulin-dependent protein kinase kinase alpha; CaM-kinase IV kinase; CaM-kinase kinase 1; CaM-kinase kinase alpha; CaM-KK 1; CaM-KK alpha; CaMKK 1; CaMKK alpha; CAMKK alpha protein; CaMKK; Camkk1; CAMKKA; DKFZp761M0423; KKCC1_HUMAN; MGC34095; OTTMUSP00000006419.  
Specific References  (1)     |     bs-11247R has been referenced in 1 publications.
[IF=4.2] Zhang, Weidong, et al. "Decrease in male mouse fertility by hydrogen sulfide and/or ammonia can Be inheritable." Chemosphere (2017).  IHC-P ;  Mouse.  
研究領(lǐng)域 神經(jīng)生物學(xué)  信號轉(zhuǎn)導(dǎo)  激酶和磷酸酶  
抗體來源 Rabbit
克隆類型 Polyclonal
克 隆 號
交叉反應(yīng) Rat (predicted: Human,Mouse,Rabbit,Pig,Sheep,Cow,Chicken,Dog,Horse)
產(chǎn)品應(yīng)用 IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 56 kDa
檢測分子量
細胞定位 細胞核 細胞漿 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human CaMKK1: 101-200/505 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 The product of this gene belongs to the Serine/Threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. This protein plays a role in the calcium/calmodulin-dependent (CaM) kinase cascade. Three transcript variants encoding two distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008].

Function:
Calcium/calmodulin-dependent protein kinase that belongs to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Phosphorylates CAMK1, CAMK1D, CAMK1G and CAMK4. Involved in regulating cell apoptosis. Promotes cell survival by phosphorylating AKT1/PKB that inhibits pro-apoptotic BAD/Bcl2-antagonist of cell death.

Subunit:
Interacts with CAMK4 and calmodulin (By similarity).

Subcellular Location:
Cytoplasm. Nucleus.

Post-translational modifications:
Appears to be autophosphorylated in a Ca(2+)/calmodulin-dependent manner. Phosphorylated at multiple sites by PRCAKA/PKA. Phosphorylation of Ser-458 is blocked upon binding to Ca(2+)/calmodulin. In vitro, phosphorylated by CAMK1 and CAMK4 (By similarity).

Similarity:
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Contains 1 protein kinase domain.

SWISS:
Q8N5S9

Gene ID:
84254

Database links:

Entrez Gene: 84254 Human

Entrez Gene: 55984 Mouse

Omim: 611411 Human

SwissProt: Q8N5S9 Human

SwissProt: Q8VBY2 Mouse

Unigene: 8417 Human

Unigene: 9998 Mouse



產(chǎn)品圖片
Paraformaldehyde-fixed, paraffin embedded (rat brain tissue); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (CaMKK1) Polyclonal Antibody, Unconjugated (bs-11247R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
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