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SORBS2 Rabbit pAb (bs-4905R)  
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產(chǎn)品編號(hào) bs-4905R
英文名稱(chēng) SORBS2 Rabbit pAb
中文名稱(chēng) 精氨酸結(jié)合蛋白2抗體
別    名 ArgBP2; Arg binding protein 2; Arg/Abl interacting protein 2; Arg/Abl interacting protein; ARGBP2; PRO0618; SRBS2_HUMAN; sorbin and SH3 domain containing 2.  
Specific References  (2)     |     bs-4905R has been referenced in 2 publications.
[IF=9.452] Tong,et al.HSF1, in association with MORC2, downregulates ArgBP2 via the PRC2 family in gastric cancer cells.(2018) Biochimica Et Biophysica Acta. 1864:1104-1114.  WB ;  Human.  
[IF=5.542] Han L et al. The RNA‐binding protein SORBS2 suppresses hepatocellular carcinoma tumorigenesis and metastasis by stabilizing RORA mRNA. Liver Int. 2019 Jul 31.  IHC ;  Human.  
研究領(lǐng)域 信號(hào)轉(zhuǎn)導(dǎo)  激酶和磷酸酶  
抗體來(lái)源 Rabbit
克隆類(lèi)型 Polyclonal
克 隆 號(hào)
交叉反應(yīng) Mouse,Rat (predicted: Human,Rabbit,Pig,Chicken,Dog,Horse)
產(chǎn)品應(yīng)用 IHC-P=1:100-500,IHC-F=1:100-500,IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 124 kDa
檢測(cè)分子量
細(xì)胞定位 細(xì)胞漿 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human SORBS2/ArgBP2: 401-500/664 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項(xiàng) This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 SORBS2 is an adapter protein that plays a role in the assembling of signaling complexes, being a link between ABL kinases and actin cytoskeleton. It can form a complex with ABL1 and CBL, thus promoting ubiquitination and degradation of ABL1 or with AKT1 and PAK1, thus mediating AKT1-mediated activation of PAK1.

Function:
Adapter protein that plays a role in the assembling of signaling complexes, being a link between ABL kinases and actin cytoskeleton. Can form complex with ABL1 and CBL, thus promoting ubiquitination and degradation of ABL1 or with AKT1 and PAK1, thus mediating AKT1-mediated activation of PAK1. Isoform 6 increases water and sodium absorption in the intestine and gall-bladder.

Subunit:
Interacts with ABL, CBL, DNM1, DNM2, FLOT1, MLLT4/afadin, PTK2B/PYK2, SAPAP, SPTAN1, SYNJ1, SYNJ2, VCL/vinculin, and WASF (By similarity). Interacts with ABL1/c-Abl, ABL2/v-Abl/Arg, ACTN, AKT1, CBL, PALLD and PAK1.

Subcellular Location:
Cytoplasm, perinuclear region. Note=Found at the Z-disk sarcomeres, stress fibers, dense bodies and focal adhesion.

Tissue Specificity:
Abundantly expressed in heart. In cardiac muscle cells, located in the Z-disks of sarcomere. Also found, but to a lower extent, in small and large intestine, pancreas, thymus, colon, spleen, prostate, testis, brain, ovary and epithelial cells.

Post-translational modifications:
Ubiquitinated by CBL.

Similarity:
Contains 3 SH3 domains.
Contains 1 SoHo domain.

SWISS:
O94875

Gene ID:
8470

Database links:

Entrez Gene: 8470 Human

Omim: 616349 Human

SwissProt: O94875 Human

Unigene: 619806 Human

Unigene: 655143 Human



產(chǎn)品圖片
Paraformaldehyde-fixed, paraffin embedded (rat brain tissue); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (SORBS2) Polyclonal Antibody, Unconjugated (bs-4905R) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
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