| 產(chǎn)品編號 | bs-9919R |
| 英文名稱 | TCN2 Rabbit pAb |
| 中文名稱 | 轉(zhuǎn)鈷胺素蛋白2抗體 |
| 別 名 | Macrocytic anemia; TC; TC II; TC-2; TC2; TCII; TCN 2; TCO2_HUMAN; Transcobalamin 2; Transcobalamin II; Transcobalamin II; macrocytic anemia; Transcobalamin-2; Vitamin B12 binding protein 2. |
| 研究領(lǐng)域 | 腫瘤 心血管 信號轉(zhuǎn)導(dǎo) |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 克 隆 號 | |
| 交叉反應(yīng) | Human (predicted: Mouse,Rat,Rabbit) |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 46 kDa |
| 檢測分子量 | |
| 細(xì)胞定位 | 分泌型蛋白 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human TCN2/Transcobalamin II: 101-200/427 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
Transcobalamin I (TCI) and Transcobalamin II (TCII) are secreted proteins belonging to the eukaryotic cobalamin transport proteins family and also to the vitamin B12-binding protein family. The genes encoding these proteins map to chromosome 11q11-q12 and 22q12.2, respectively. Transcobalamin I is a constituent of secondary granules in neutrophils, while Transcobalamin II binds cobalamin and mediates its transport into cells. These plasma proteins are expressed in various tissues and secretions. Function: Primary vitamin B12-binding and transport protein. Delivers cobalamin to cells. Subcellular Location: Secreted. DISEASE: Defects in TCN2 are the cause of transcobalamin II deficiency (TCN2 deficiency) [MIM:275350]. This results in various forms of anemia. Similarity: Belongs to the eukaryotic cobalamin transport proteins family. SWISS: P20062 Gene ID: 6948 Database links: Entrez Gene: 6948 Human Omim: 275350 Human SwissProt: P20062 Human Unigene: 417948 Human Involvement in disease;Defects in TCN2 are the cause of transcobalamin II deficiency (TCN2 deficiency) [MIM:275350]. This results in various forms of anemia. |
| 產(chǎn)品圖片 |
25 ug total protein per lane of various lysates (see on figure) probed with TCN2 polyclonal antibody, unconjugated (bs-9919R) at 1:1000 dilution and 4°C overnight incubation. Followed by conjugated secondary antibody incubation at r.t. for 60 min.
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