| 產(chǎn)品編號 | bs-3904R |
| 英文名稱 | HSD11B1 Rabbit pAb |
| 中文名稱 | 羥基類固醇脫氫酶11β1抗體 |
| 別 名 | 11 beta HSD 1; 11 beta HSD1; 11 beta hydroxysteroid dehydrogenase 1; 11 DH; 11DH; Corticosteroid 11 beta dehydrogenase isozyme 1; HDL; HSD 11; HSD11; HSD11B; HSD11L; Hydroxysteroid(11 beta) dehydrogenase 1; Hydroxysteroid(11 beta) dehydrogenase; MGC13539. |
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Specific References (2) | bs-3904R has been referenced in 2 publications.
[IF=10.588] Tianxin Zhao. et al. Prenatal exposure to environmentally relevant levels of PBDE-99 leads to testicular dysgenesis with steroidogenesis disorders. J Hazard Mater. 2022 Feb;424:127547 IHC ; Mouse.
[IF=1.21] Nakata, Takaya, et al. "The expression of 11β-hydroxysteroid dehydrogenase type 1 is increased in experimental periodontitis in rats." BMC Oral Health16.1 (2016): 108. IHC-P ; Rat.
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| 研究領(lǐng)域 | 腫瘤 細(xì)胞生物 免疫學(xué) 轉(zhuǎn)錄調(diào)節(jié)因子 激酶和磷酸酶 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 克 隆 號 | |
| 交叉反應(yīng) | Human,Mouse,Rat,Horse (predicted: Rabbit,Pig,Sheep,Cow,Dog) |
| 產(chǎn)品應(yīng)用 | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 32 kDa |
| 檢測分子量 | |
| 細(xì)胞定位 | 細(xì)胞漿 細(xì)胞膜 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human HSD11B1: 201-292/292 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
HSD11B1 is a microsomal enzyme that catalyses the conversion of the stress hormone cortisol to the inactive metabolite cortisone. In addition, the encoded protein can catalyse the reverse reaction, the conversion of cortisone to cortisol. Too much cortisol can lead to central obesity, and a particular variation in this gene has been associated with obesity and insulin resistance in children. Two transcript variants encoding the same protein have been found for this gene. Subunit: Homodimer. Subcellular Location: Endoplasmic reticulum membrane; Single-pass type II membrane protein. Tissue Specificity: Widely expressed. Highest expression in liver. Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family. SWISS: P28845 Gene ID: 3290 Database links: Entrez Gene: 3290 Human Entrez Gene: 15483 Mouse Omim: 600713 Human SwissProt: Q6R0J2 Hamster SwissProt: P28845 Human SwissProt: P50172 Mouse SwissProt: Q7M3I4 Rabbit Unigene: 195040 Human Unigene: 28328 Mouse Unigene: 185798 Rat Unigene: 888 Rat |
| 產(chǎn)品圖片 |
This image was kindly submitted by Dragos Scarlet DVM, MSc from the University of Vienna as part of the Bioss Discovery Progarm. Paraffin embedded horse kidney labeled with Anti-HSD11B1 Polyclonal Antibody, Unconjugated (bs-3904R) at 1:200 followed by conjugation to the secondary antibody and DAB staining
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