| 產(chǎn)品編號(hào) | bs-2531R |
| 英文名稱 | NES/Kallikrein 10 Rabbit pAb |
| 中文名稱 | 上皮細(xì)胞特異性蛋白1抗體 |
| 別 名 | Kallikrein 10; Breast normal epithelial cell associated serine protease; Kallikrein related peptidase 10; KLK 10; KLK10; KLK10_HUMAN; NES 1; NES1; Normal epithelial cell specific 1; Protease serine like 1; PRSS L1; PRSSL 1; PRSSL1. |
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Specific References (3) | bs-2531R has been referenced in 3 publications.
[IF=2.559] Cao XY et al. Aberrant upregulation of KLK10 promotes metastasis via enhancement of EMT and FAK/SRC/ERK axis in PDAC.Biochem Biophys Res Commun. 2018 May 15;499(3):584-593. IHC-P&WB ; Mouse&Human.
[IF=2.3] Li, Lei, et al. "Upregulated KLK10 inhibits esophageal cancer proliferation and enhances cisplatin sensitivity in vitro." Oncology Reports. WB ;
[IF=0] Wang et al. Chemoprevention activity of dipyridamole in the MMTV-PyMT transgenic mouse model of breast cancer. (2013) Cancer.Prev.Res.(Phila. 6:437-47 WB ; Human.
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| 研究領(lǐng)域 | 腫瘤 細(xì)胞生物 信號(hào)轉(zhuǎn)導(dǎo) 激酶和磷酸酶 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 克 隆 號(hào) | |
| 交叉反應(yīng) | Human (predicted: Mouse,Rat,Cow) |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 31 kDa |
| 檢測分子量 | |
| 細(xì)胞定位 | 分泌型蛋白 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human KLK10: 65-165/276 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
Kallikrein 10 is a trypsin-like serine proteinase. Originally described from a subtractive library looking for genes that were down-regulated in breast cancer, kallikrein 10 was thought to be epithelial cell specific. Kallikrein 10 is reported to be up regulated in pancreatic cancer and ovarian cancer, but down regulated in testicular cancer and breast cancer, perhaps due to differential hormonal regulation, or tissue specificities. Breast cancer patients that had elevated kallikrein 10 had a worse prognosis, leading to speculation that kallikrein 10 might be protective in breast cancer, similar to the argument put forth for kallikrein 3 in prostate cancer. Kallikrein 10 is found in high levels in the pancreas and in lower levels in the tonsils, esophagus, skin, brain, testis and ovary. Biological fluids (breast milk, serum, seminal plasma, urine) contain kallikrein 10, the highest levels found in milk. The cerebral spinal fluid (CSF) contains Kallikrein 10, and was reported to be elevated in patients with Alzheimer’s disease. Endogenous inhibitors include kallistatin, protein-C inhibitor and 1-proteinase inhibitor, although Kallikrein 10 can be found complexed to a number of different proteinase inhibitors. Function: Has a tumor-suppressor role for NES1 in breast and prostate cancer. Subcellular Location: Secreted. Tissue Specificity: Expressed in breast, ovary and prostate. Similarity: Belongs to the peptidase S1 family. Kallikrein subfamily. Contains 1 peptidase S1 domain. SWISS: O43240 Gene ID: 5655 Database links: Entrez Gene: 5655 Human Omim: 602673 Human SwissProt: O43240 Human Unigene: 275464 Human KLK10是組織激肽釋放酶基因家族的重要成員,是當(dāng)前研究較熱的腫瘤生物學(xué)標(biāo)志物之一,在多種與內(nèi)分泌相關(guān)的腫瘤中有較特異性的表達(dá)。 |
| 產(chǎn)品圖片 |
Sample:
DU145(Human) Cell Lysate at 30 ug
Primary: Anti-NES/Kallikrein 10 (bs-2531R) at 1/300 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 31 kD
Observed band size: 31 kD
Sample:
MCF-7(Human) Cell Lysate at 30 ug
Primary: Anti-NES/Kallikrein 10 (bs-2531R) at 1/300 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 31 kD
Observed band size: 31 kD
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