| 產(chǎn)品編號(hào) | bs-1768R |
| 英文名稱 | FGFBP1 Rabbit pAb |
| 中文名稱 | 纖維細(xì)胞生長(zhǎng)因子結(jié)合蛋白抗體 |
| 別 名 | FGF-binding protein; 17 kDa heparin binding growth factor binding protein; FGF binding protein 1; FGF BP; FGF BP1; FGF-BP; FGFBP; FGFBP1; Fibroblast growth factor binding protein 1 precursor; HBP17; FGFP1_HUMAN. |
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Specific References (5) | bs-1768R has been referenced in 5 publications.
[IF=9.802] Alba Blascoet al. Motoneuron deafferentation and gliosis occur in association with neuromuscular regressive changes during ageing in mice. J Cachexia Sarcopenia Muscle
. 2020 Dec;11(6):1628-1660. ICC ; mouse.
[IF=5.99] Taetzsch et al. Muscle Fibers Secrete FGFBP1 to Slow Degeneration of Neuromuscular Synapses during Aging and Progression of ALS. (2017) J.Neurosc. 37:70-82 IHC ; Mouse.
[IF=5.94] Taetzsch, Thomas, Milagros J. Tenga, and Gregorio Valdez. "Muscle fibers secrete FGFBP1 to slow degeneration of neuromuscular synapses during aging and progression of ALS." Journal of Neuroscience (2016): 2992-16. IHC-F ; Mouse.
[IF=5.93] Asparuhova, Maria B., et al. "Mechanism of irradiation-induced mammary cancer metastasis: A role for SAP-dependent Mkl1 signaling." Molecular Oncology (2015). WB ; Mouse.
[IF=5.611] Azzurra Cottarelli. et al. Fgfbp1 promotes blood-brain barrier development by regulating collagen IV deposition and maintaining Wnt/β-catenin signaling. Development. 2020 Aug;147(16) IF ; Mouse.
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| 研究領(lǐng)域 | 腫瘤 免疫學(xué) |
| 抗體來(lái)源 | Rabbit |
| 克隆類型 | Polyclonal |
| 克 隆 號(hào) | |
| 交叉反應(yīng) | Human,Mouse (predicted: Rat) |
| 產(chǎn)品應(yīng)用 | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 23 kDa |
| 檢測(cè)分子量 | |
| 細(xì)胞定位 | 細(xì)胞膜 分泌型蛋白 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human FGFBP: 151-234/234 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
This gene encodes a secreted fibroblast growth factor carrier protein. The encoded protein plays a critical role in cell proliferation, differentiation and migration by binding to fibroblast growth factors and potentiating their biological effects on target cells. The encoded protein may also play a role in tumor growth as an angiogenic switch molecule, and expression of this gene has been associated with several types of cancer including pancreatic and colorectal adenocarcinoma. A pseudogene of this gene is also located on the short arm of chromosome 4. [provided by RefSeq, Nov 2011] Function: Acts as a carrier protein that release fibroblast-binding factors (FGFs) from the extracellular matrix (EM) storage and thus enhance the mitogenic activity of FGFs. Enhances FGF2 signaling during tissue repair, angiogenesis and in tumor growth. Subunit: Found in a complex with FGFBP1, FGF1 and FGF2. Interacts with FGF1, FGF2, FGF7, FGF10, FGF22 and HSPG2. Subcellular Location: Secreted, extracellular space. Cell membrane; Peripheral membrane protein. Note=Extracellular and plasma membrane-associated. Colocalizes with HSPG2 in the pericellular environment of squamous cell carcinomas. Tissue Specificity: Expressed in the suprabasal region of the epidermis, in hair follicles, the basement membrane at the dermo-epidermal junction (occasionally extending into the basement membrane of dermal blood vessels), wounded skin and several invasive squamous cell carcinomas (at protein level). Expressed in normal and wounded skin and various squamous cell carcinomas. Similarity: Belongs to the fibroblast growth factor-binding protein family. SWISS: Q14512 Gene ID: 9982 Database links: Entrez Gene: 9982 Human Omim: 607737 Human SwissProt: Q14512 Human Unigene: 1690 Human |
| 產(chǎn)品圖片 |
Paraformaldehyde-fixed, paraffin embedded (human skin cancer); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (FGFBP1) Polyclonal Antibody, Unconjugated (bs-1768R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
Tissue/cell: mouse stomach tissue; 4% Paraformaldehyde-fixed and paraffin-embedded;
Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min;
Incubation: Anti-FGFBP1 Polyclonal Antibody, Unconjugated(bs-1768R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining
Tissue/cell: mouse intestine tissue; 4% Paraformaldehyde-fixed and paraffin-embedded;
Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min;
Incubation: Anti-FGFBP1 Polyclonal Antibody, Unconjugated(bs-1768R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining
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